Antigenic analysis of H2 influenza virus haemagglutinin with monoclonal antibodies
Identifieur interne : 002454 ( Main/Exploration ); précédent : 002453; suivant : 002455Antigenic analysis of H2 influenza virus haemagglutinin with monoclonal antibodies
Auteurs : A. Yamada [États-Unis] ; I. E. Brown [États-Unis] ; R. G. Webster [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 1985.
English descriptors
- Teeft :
- Antigenic, Antigenic analysis, Antigenic differences, Antigenic drift, Antigenic regions, Avian, Avian influenza viruses, Haemagglutinin, Horse serum, Horse serum inhibitor, Influenza, Influenza virus, Influenza virus haemagglutinin, Influenza viruses, Inhibitor, Minor antigenic variation, Monoclonal, Monoclonal antibodies, Multiple variants, Receptor, Significant antigenic drift, Similar results, Virology, Virus.
Abstract
Abstract: Antigenic analysis of human and avian H2 influenza virus was carried out with monoclonal antibodies to the HA molecules of H2 influenza viruses isolated in the early stage of an H2 pandemic. The study revealed antigenic differences between inhibitor sensitive (Japan+/57, RI+57) and inhibitor resistant strains (Japan−/57, Ri−/57). This indicates that the receptor-binding specificity of the haemagglutinin can markedly influence the antigenic analysis obtained with monoclonal antibodies in HI test. Minor antigenic differences (microheterogeneity) could be detected between different H2 influenza viruses isolated in 1957. Minor antigenic variation continued in the H2 viruses until 1961, but significant antigenic drift occurred in 1962 so that viruses isolated after that date reacted with few monoclonal antibodies. Analysis of avian H2 influenza viruses suggested antigenic differences between the different avian H2 haemagglutinin but no correlation between the year of isolation and the progressive antigenic drift similar to that seen in the human strains was found.
Url:
DOI: 10.1016/0264-410X(85)90102-1
Affiliations:
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Yamada</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P.O. Box 318 Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Brown, I E" sort="Brown, I E" uniqKey="Brown I" first="I. E." last="Brown">I. E. Brown</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P.O. Box 318 Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P.O. Box 318 Memphis</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="195">195</biblScope><biblScope unit="page" to="198">198</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antigenic</term><term>Antigenic analysis</term><term>Antigenic differences</term><term>Antigenic drift</term><term>Antigenic regions</term><term>Avian</term><term>Avian influenza viruses</term><term>Haemagglutinin</term><term>Horse serum</term><term>Horse serum inhibitor</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus haemagglutinin</term><term>Influenza viruses</term><term>Inhibitor</term><term>Minor antigenic variation</term><term>Monoclonal</term><term>Monoclonal antibodies</term><term>Multiple variants</term><term>Receptor</term><term>Significant antigenic drift</term><term>Similar results</term><term>Virology</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Antigenic analysis of human and avian H2 influenza virus was carried out with monoclonal antibodies to the HA molecules of H2 influenza viruses isolated in the early stage of an H2 pandemic. The study revealed antigenic differences between inhibitor sensitive (Japan+/57, RI+57) and inhibitor resistant strains (Japan−/57, Ri−/57). This indicates that the receptor-binding specificity of the haemagglutinin can markedly influence the antigenic analysis obtained with monoclonal antibodies in HI test. Minor antigenic differences (microheterogeneity) could be detected between different H2 influenza viruses isolated in 1957. Minor antigenic variation continued in the H2 viruses until 1961, but significant antigenic drift occurred in 1962 so that viruses isolated after that date reacted with few monoclonal antibodies. Analysis of avian H2 influenza viruses suggested antigenic differences between the different avian H2 haemagglutinin but no correlation between the year of isolation and the progressive antigenic drift similar to that seen in the human strains was found.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Yamada, A" sort="Yamada, A" uniqKey="Yamada A" first="A." last="Yamada">A. Yamada</name></region><name sortKey="Brown, I E" sort="Brown, I E" uniqKey="Brown I" first="I. E." last="Brown">I. E. Brown</name><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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